RETRACTED: MicroRNA-498 disturbs the occurrence and aggression of colon cancer through targeting MDM2 to mediate PPARγ ubiquitination

Life Sci. 2021 Jul 15:277:119225. doi: 10.1016/j.lfs.2021.119225. Epub 2021 Feb 19.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concern was raised about the reliability of this article that shares several characteristics with other articles in the eyebrow family of publications, tabulated here (https://docs.google.com/spreadsheets/d/149EjFXVxpwkBXYJOnOHb6RhAqT4a2llhj9LM60MBffM/edit#gid=0). In addition, Fig. 5A appears to show a digital composition of xenografted tumors. The journal requested the corresponding author comment on these concerns and provide the raw data. However the authors were not able to satisfactorily fulfil this request and therefore the Editor-in-Chief decided to retract the article.

Keywords: Colon cancer; MicroRNA-498; Mouse double minute 2; Peroxisome proliferator-activated receptor γ; Tumorigenesis; Ubiquitination.

Publication types

  • Retracted Publication

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Apoptosis / genetics
  • Carcinogenesis / genetics
  • Cell Line, Tumor
  • Cell Proliferation / genetics
  • Cell Survival / genetics
  • China
  • Colonic Neoplasms / genetics*
  • Colonic Neoplasms / metabolism
  • Female
  • Gene Expression Regulation, Neoplastic / genetics
  • Humans
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Middle Aged
  • PPAR gamma / metabolism
  • PPAR gamma / physiology
  • Prognosis
  • Proto-Oncogene Proteins c-mdm2 / genetics
  • Proto-Oncogene Proteins c-mdm2 / metabolism*
  • Transcriptional Activation / genetics
  • Ubiquitination
  • Xenograft Model Antitumor Assays / methods

Substances

  • MIRN498 microRNA, human
  • MicroRNAs
  • PPAR gamma
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2