PRR34-AS1 sponges miR-498 to facilitate TOMM20 and ITGA6 mediated tumor progression in HCC

Exp Mol Pathol. 2021 Jun:120:104620. doi: 10.1016/j.yexmp.2021.104620. Epub 2021 Feb 17.

Abstract

Background: The researches on PRR34 antisense RNA 1 (PRR34-AS1) have been limited. Both translocase of outer mitochondrial membrane 20 (TOMM20) and integrin subunit alpha 6 (ITGA6) have been proven to facilitate cancer progression. Whether TOMM20 or ITGA6 affects hepatocellular carcinoma (HCC) progression has never been investigated. Some studies showed that microRNA 498 (miR-498) can suppress HCC progression. Additionally, the influence of ceRNA network (including PRR34-AS1, miR-498, and TOMM20 or ITGA6) on HCC progression has not been inquired into yet.

Methods: The knockdown or overexpression efficiency was validated via RT-qPCR. Also, RT-qPCR was applied to detect the expression of PRR34-AS1, miR-498, TOMM20, and ITGA6. Cell proliferation in HCC was tested via EdU and colony formation assays. Transwell assays presented the migratory and invasive capabilities of HCC cells. Subcellular fractionation and FISH assays showed the subcellular localization of PRR34-AS1. RNA pull down and luciferase reporter assays were performed to explore whether miR-498 combines with PRR34-AS1, TOMM20 or ITGA6. Western blot was conducted to detect protein expression. Rescue experiments were conducted to verify the relationship among PRR34-AS1, miR-498, TOMM20, and ITGA6.

Results: The expressions of PRR34-AS1, TOMM20, and ITGA6 were markedly high in HCC cell lines while miR-498 was lowly expressed. PRR34-AS1, TOMM20, and ITGA6 promoted HCC progression while miR-498 suppressed cell proliferation, migration, and invasion in HCC. Furthermore, PRR34-AS1, TOMM20, and ITGA6 combined with miR-498.

Conclusion: PRR34-AS1 facilitates HCC progression by regulating miR-498/TOMM20/ITGA6 axis.

Keywords: Hepatocellular carcinoma; ITGA6; PRR34-AS1; TOMM20; miR-498.

MeSH terms

  • Apoptosis
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism
  • Carcinoma, Hepatocellular / genetics
  • Carcinoma, Hepatocellular / metabolism
  • Carcinoma, Hepatocellular / pathology*
  • Cell Proliferation
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Integrin alpha6 / genetics
  • Integrin alpha6 / metabolism*
  • Liver Neoplasms / genetics
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / pathology
  • Membrane Transport Proteins / genetics
  • Membrane Transport Proteins / metabolism*
  • MicroRNAs / genetics*
  • Mitochondrial Precursor Protein Import Complex Proteins
  • RNA, Antisense / genetics*
  • RNA, Long Noncoding / genetics*
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism*
  • Tumor Cells, Cultured

Substances

  • Biomarkers, Tumor
  • ITGA6 protein, human
  • Integrin alpha6
  • MIRN498 microRNA, human
  • Membrane Transport Proteins
  • MicroRNAs
  • Mitochondrial Precursor Protein Import Complex Proteins
  • RNA, Antisense
  • RNA, Long Noncoding
  • Receptors, Cell Surface
  • TOMM20 protein, human