Shiga Toxin-Producing Escherichia coli Transmission via Fecal Microbiota Transplant

Caroline Zellmer; Mohamad R A Sater; Miriam H Huntley; Majdi Osman; Scott W Olesen; Bharat Ramakrishna

doi:10.1093/cid/ciaa1486

Shiga Toxin-Producing Escherichia coli Transmission via Fecal Microbiota Transplant

Clin Infect Dis. 2021 Jun 1;72(11):e876-e880. doi: 10.1093/cid/ciaa1486.

Authors

Caroline Zellmer¹, Mohamad R A Sater², Miriam H Huntley², Majdi Osman¹, Scott W Olesen¹, Bharat Ramakrishna¹

Affiliations

¹ OpenBiome, Cambridge, Massachusetts, USA.
² Day Zero Diagnostics, Allston, Massachusetts, USA.

PMID: 33159210
DOI: 10.1093/cid/ciaa1486

Abstract

Fecal microbiota transplantation (FMT) is recommended therapy for multiply recurrent Clostridioides difficile infection. We report adverse events in 7 patients who received FMT from a stool donor who was colonized with Shiga toxin-producing Escherichia coli (STEC). No patients died of FMT-transmitted STEC. Improved screening can likely avoid future transmission.

Keywords: Clostridioides difficile; FMT; STEC; Shiga toxin-producing E. coli; fecal microbiota transplantation.

MeSH terms

Clostridioides difficile*
Clostridium Infections*
Escherichia coli Infections*
Fecal Microbiota Transplantation
Feces
Humans
Microbiota*
Shiga-Toxigenic Escherichia coli*