Rate of regrowth of damaged retinal ganglion cell axons regenerating in a peripheral nerve graft in adult hamsters

Brain Res. 1987 Sep 1;419(1-2):369-74. doi: 10.1016/0006-8993(87)90610-x.

Abstract

The rate of regrowth of ganglion cell axons regenerating into a peripheral nerve graft implanted into the retina of adult hamster was measured, utilizing the method of retrograde labelling by horseradish peroxidase. The fastest regrowing axons were found, after an initial delay of 4.5 days, to extend at about 2 mm/day in the graft. The role of the cell body in controlling the rate of axonal regeneration was briefly discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axons / physiology*
  • Cricetinae
  • Horseradish Peroxidase
  • Mesocricetus
  • Nerve Regeneration*
  • Retina / physiology*
  • Retinal Ganglion Cells / cytology
  • Retinal Ganglion Cells / physiology*
  • Sciatic Nerve / physiology*
  • Time Factors

Substances

  • Horseradish Peroxidase