Redefining prognostication of de novo cytogenetically normal acute myeloid leukemia in young adults

Sze P Tsui; Ho W Ip; Nicole Y Saw; Chunxiao Zhang; Arthur K Cheung; Nelson K Ng; Cheuk H Man; Stephen S Lam; Wing F Tang; Chi H Lin; Grace H Cheng; Chun H Au; Edmond S Ma; Tsun L Chan; Jason C So; Margaret H Ng; Kelvin C Cheng; Kit F Wong; Lai P Siu; Sze F Yip; Shek Y Lin; June S Lau; Tsan H Luk; Harold K Lee; Chi K Lau; Bonnie Kho; Joycelyn P Sim; Yok L Kwong; Suet Y Leung; Asif Javed; Anskar Y Leung

doi:10.1038/s41408-020-00373-4

Redefining prognostication of de novo cytogenetically normal acute myeloid leukemia in young adults

Blood Cancer J. 2020 Oct 19;10(10):104. doi: 10.1038/s41408-020-00373-4.

Authors

Sze P Tsui¹, Ho W Ip¹, Nicole Y Saw², Chunxiao Zhang³, Arthur K Cheung^{4

5}, Nelson K Ng³, Cheuk H Man³, Stephen S Lam³, Wing F Tang¹, Chi H Lin⁴, Grace H Cheng⁴, Chun H Au⁶, Edmond S Ma⁶, Tsun L Chan⁶, Jason C So⁷, Margaret H Ng⁸, Kelvin C Cheng⁸, Kit F Wong⁹, Lai P Siu⁹, Sze F Yip¹⁰, Shek Y Lin¹¹, June S Lau¹², Tsan H Luk¹², Harold K Lee¹³, Chi K Lau¹⁴, Bonnie Kho¹⁵, Joycelyn P Sim³, Yok L Kwong³, Suet Y Leung^{4

5

16}, Asif Javed^{17

18

19}, Anskar Y Leung^{20

21}

Affiliations

¹ Department of Pathology, Queen Mary Hospital, Hong Kong SAR, China.
² School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
³ Division of Haematology, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
⁴ Centre for PanorOmic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
⁵ The Jockey Club Centre for Clinical Innovation and Discovery, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
⁶ Department of Pathology, Hong Kong Sanatorium and Hospital, Hong Kong SAR, China.
⁷ Department of Pathology, Hong Kong Children's Hospital, Hong Kong SAR, China.
⁸ Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China.
⁹ Department of Pathology, Queen Elizabeth Hospital, Hong Kong SAR, China.
¹⁰ Department of Pathology, Tuen Mun Hospital, Hong Kong SAR, China.
¹¹ Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong SAR, China.
¹² Department of Medicine, Queen Elizabeth Hospital, Hong Kong SAR, China.
¹³ Department of Medicine, Princess Margaret Hospital, Hong Kong SAR, China.
¹⁴ Department of Medicine, Tseung Kwan O Hospital, Hong Kong SAR, China.
¹⁵ Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China.
¹⁶ Department of Pathology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
¹⁷ School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. javed@hku.hk.
¹⁸ Centre for PanorOmic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. javed@hku.hk.
¹⁹ The Jockey Club Centre for Clinical Innovation and Discovery, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. javed@hku.hk.
²⁰ Division of Haematology, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. ayhleung@hku.hk.
²¹ The Jockey Club Centre for Clinical Innovation and Discovery, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. ayhleung@hku.hk.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Disease-Free Survival
Female
Humans
Idarubicin / administration & dosage
Leukemia, Myeloid, Acute* / drug therapy
Leukemia, Myeloid, Acute* / genetics
Leukemia, Myeloid, Acute* / mortality
Male
Middle Aged
Mitoxantrone / administration & dosage
Survival Rate
Young Adult

Substances

Mitoxantrone
Idarubicin