SARS-CoV-2 infects human neural progenitor cells and brain organoids

Bao-Zhong Zhang; Hin Chu; Shuo Han; Huiping Shuai; Jian Deng; Ye-Fan Hu; Hua-Rui Gong; Andrew Chak-Yiu Lee; Zijiao Zou; Thomas Yau; Wutian Wu; Ivan Fan-Ngai Hung; Jasper Fuk-Woo Chan; Kwok-Yung Yuen; Jian-Dong Huang

doi:10.1038/s41422-020-0390-x

SARS-CoV-2 infects human neural progenitor cells and brain organoids

Cell Res. 2020 Oct;30(10):928-931. doi: 10.1038/s41422-020-0390-x. Epub 2020 Aug 4.

Authors

Bao-Zhong Zhang^#^{1

2}, Hin Chu^#³, Shuo Han^#¹, Huiping Shuai^#⁴, Jian Deng¹, Ye-Fan Hu^{1

5}, Hua-Rui Gong¹, Andrew Chak-Yiu Lee⁴, Zijiao Zou⁴, Thomas Yau⁵, Wutian Wu^{1

6

7}, Ivan Fan-Ngai Hung⁵, Jasper Fuk-Woo Chan^{4

8}, Kwok-Yung Yuen^{9

10}, Jian-Dong Huang^{11

12}

Affiliations

¹ School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 3/F, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China.
² CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.
³ Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. hinchu@hku.hk.
⁴ Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
⁵ Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
⁶ Guangdong-Hongkong-Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou, Guangdong, 510632, China.
⁷ Re-Stem Biotech, Suzhou, Jiangsu, 330520, China.
⁸ State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong, China.
⁹ Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. kyyuen@hkucc.hku.hk.
¹⁰ State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong, China. kyyuen@hkucc.hku.hk.
¹¹ School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 3/F, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China. jdhuang@hku.hk.
¹² CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China. jdhuang@hku.hk.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Betacoronavirus / isolation & purification
Betacoronavirus / physiology*
Brain / pathology
Brain / virology*
COVID-19
Cell Line
Cell Survival
Coronavirus Infections / complications
Coronavirus Infections / pathology*
Coronavirus Infections / virology
Humans
Nervous System Diseases / pathology
Nervous System Diseases / virology
Neural Stem Cells / pathology
Neural Stem Cells / virology*
Organoids / pathology
Organoids / virology
Pandemics
Pneumonia, Viral / complications
Pneumonia, Viral / pathology*
Pneumonia, Viral / virology
SARS-CoV-2

Grants and funding

2019M663167/China Postdoctoral Science Foundation/International