Long non-coding RNA HEIH suppresses the expression of TP53 through enhancer of zeste homolog 2 in oesophageal squamous cell carcinoma

XinYu Ding; Chen Qi; Jie Min; ZhiFei Xu; KeNan Huang; Hua Tang

doi:10.1111/jcmm.15673

Long non-coding RNA HEIH suppresses the expression of TP53 through enhancer of zeste homolog 2 in oesophageal squamous cell carcinoma

J Cell Mol Med. 2020 Sep;24(18):10551-10559. doi: 10.1111/jcmm.15673. Epub 2020 Jul 30.

Authors

XinYu Ding¹, Chen Qi², Jie Min¹, ZhiFei Xu¹, KeNan Huang¹, Hua Tang¹

Affiliations

¹ Department of Minimally Invasive Thoracic Surgery Center, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
² Department of Cardiothoracic Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Abstract

It is increasingly evident that the molecular and biological functions of long non-coding RNAs (lncRNA) are vital for understanding the molecular biology and progression of cancer. The lncRNA-HEIH, a newly identified lncRNA, has been demonstrated to be up-regulated in hepatocellular cancer. However, little is known about its role in oesophageal squamous cell carcinoma (ESCC). In the present study, an obvious up-regulation of lncRNA-HEIH was observed in ESCC compared to the adjacent normal tissues. Meanwhile, patients with high expression of lncRNA-HEIH have significantly poorer prognosis than those with low expression. We further found that lncRNA-HEIH was associated with enhancer of zeste homolog 2 (EZH2) and that this association led to the repression of TP53. These findings indicate that lncRNA-HEIH may serve as a prognostic marker and a potential therapeutic target for ESCC.

Keywords: TP53; lncRNA-HEIH; long non-coding RNA; oesophageal squamous cell carcinoma; zeste homolog 2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Animals
Disease-Free Survival
Enhancer of Zeste Homolog 2 Protein / antagonists & inhibitors
Enhancer of Zeste Homolog 2 Protein / genetics
Enhancer of Zeste Homolog 2 Protein / physiology*
Esophageal Neoplasms / genetics*
Esophageal Neoplasms / mortality
Esophageal Neoplasms / pathology
Esophageal Squamous Cell Carcinoma / genetics*
Esophageal Squamous Cell Carcinoma / mortality
Esophageal Squamous Cell Carcinoma / pathology
Female
Gene Expression Regulation, Neoplastic / genetics*
Gene Regulatory Networks
Genes, Reporter
Genes, p53
Humans
Kaplan-Meier Estimate
Male
Mice, Inbred BALB C
Mice, Nude
Middle Aged
Neoplasm Invasiveness
Neoplasm Proteins / antagonists & inhibitors
Neoplasm Proteins / biosynthesis
Neoplasm Proteins / genetics
Neoplasm Proteins / physiology*
Neoplasm Transplantation
Polycomb Repressive Complex 2 / metabolism
RNA / genetics
RNA / metabolism
RNA, Long Noncoding / genetics
RNA, Long Noncoding / metabolism*
RNA, Neoplasm / genetics*
RNA, Small Interfering / genetics
RNA, Small Interfering / pharmacology
Tumor Suppressor Protein p53 / biosynthesis*
Up-Regulation

Substances

Neoplasm Proteins
RNA, Long Noncoding
RNA, Neoplasm
RNA, Small Interfering
RNA, recombinant
TP53 protein, human
Tumor Suppressor Protein p53
RNA
EZH2 protein, human
Enhancer of Zeste Homolog 2 Protein
Polycomb Repressive Complex 2