Cancer-associated histone mutation H2BG53D disrupts DNA-histone octamer interaction and promotes oncogenic phenotypes

Yi Ching Esther Wan; Tsz Chui Sophia Leung; Dongbo Ding; Xulun Sun; Jiaxian Liu; Lina Zhu; Tze Zhen Evangeline Kang; Du Yang; Yuchen Zhang; Jitian Zhang; Chengmin Qian; Michael Shing Yan Huen; Qing Li; Maggie Zi Ying Chow; Zongli Zheng; Junhong Han; Ajay Goel; Xin Wang; Toyotaka Ishibashi; Kui Ming Chan

doi:10.1038/s41392-020-0131-0

Cancer-associated histone mutation H2BG53D disrupts DNA-histone octamer interaction and promotes oncogenic phenotypes

Signal Transduct Target Ther. 2020 Mar 6;5(1):27. doi: 10.1038/s41392-020-0131-0.

Authors

Yi Ching Esther Wan^#^{1

2}, Tsz Chui Sophia Leung^#³, Dongbo Ding^#³, Xulun Sun³, Jiaxian Liu^{1

2}, Lina Zhu^{1

2}, Tze Zhen Evangeline Kang^{1

2}, Du Yang⁴, Yuchen Zhang^{1

2}, Jitian Zhang^{1

2}, Chengmin Qian⁵, Michael Shing Yan Huen⁵, Qing Li⁴, Maggie Zi Ying Chow⁶, Zongli Zheng^{1

2

6}, Junhong Han⁷, Ajay Goel⁸, Xin Wang^{9

10}, Toyotaka Ishibashi¹¹, Kui Ming Chan^{12

13}

Affiliations

¹ Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
² Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, China.
³ Division of Life Science, Hong Kong University of Science and Technology, Hong Kong, China.
⁴ State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Peking, China.
⁵ School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China.
⁶ Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong, China.
⁷ State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan, China.
⁸ Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
⁹ Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China. Xin.wang@cityu.edu.hk.
¹⁰ Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, China. Xin.wang@cityu.edu.hk.
¹¹ Division of Life Science, Hong Kong University of Science and Technology, Hong Kong, China. Toyotaka@ust.hk.
¹² Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China. Ming.chan@cityu.edu.hk.
¹³ Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, China. Ming.chan@cityu.edu.hk.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cell Proliferation / genetics
Clustered Regularly Interspaced Short Palindromic Repeats / genetics
DNA / genetics*
DNA / ultrastructure
DNA-Binding Proteins / genetics*
DNA-Binding Proteins / ultrastructure
Histones / genetics*
Histones / ultrastructure
Humans
Mutation / genetics
Neoplasms / genetics*
Neoplasms / pathology
Nucleic Acid Conformation
Nucleosomes / genetics
Oncogenes / genetics
Phenotype

Substances

DNA-Binding Proteins
Histones
Nucleosomes
DNA

Publication types

MeSH terms

Substances

Grants and funding