Abstract
A BODIPY-based fluorescent sensor PS with an NO4S2 podand ligand was studied for the selective detection of Pt2+ over 21 cations as well as selected platinum drugs in aqueous medium. The platinum sensor PS shows 28-fold, 22-fold and 14-fold fluorescence turn-on enhancements to Pt2+, cisplatin and nedaplatin, and was thereby employed to detect platinum drugs in A-549 human lung cancer cells.
MeSH terms
-
A549 Cells
-
Boron Compounds / chemistry*
-
Cisplatin / analysis*
-
Cisplatin / therapeutic use
-
Fluorescent Dyes / chemistry*
-
Humans
-
Ligands
-
Lung Neoplasms / diagnostic imaging*
-
Lung Neoplasms / drug therapy
-
Molecular Structure
-
Optical Imaging
-
Platinum / analysis*
-
Spectrometry, Fluorescence
Substances
-
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
-
Boron Compounds
-
Fluorescent Dyes
-
Ligands
-
Platinum
-
Cisplatin