Utilizing daily excessive concentration hours to estimate cardiovascular mortality and years of life lost attributable to fine particulate matter in Tehran, Iran

Background: Evidence for associations between fine particulate matter (PM_2.5) and cardiovascular diseases (CVDs) in Iran is scarce. Given large within-day variations of PM_2.5 concentration, using the daily mean of PM_2.5 (PM_2.5mean) as exposure metric might bias the health-related assessment. This study applied a novel indicator, daily excessive concentration hours (DECH), to evaluate the effect of ambient PM_2.5 on CVD mortality and years of life lost (YLL) in Tehran, the capital city of Iran.

Methods: Hourly concentration data for PM_2.5, daily information for meteorology and records of registered cardiovascular deaths from 2012 to 2016 were obtained from Tehran, Iran. Daily excessive concentration hours of PM_2.5 (PM_2.5DECH) was defined as daily total concentration-hours exceeding 35 μg/m³. Using a time-series design, we applied generalized linear models to assess the attributable effects of PM_2.5DECH and PM_2.5mean on CVD mortality and YLL.

Results: For an interquartile range (IQR) rise in PM_2.5DECH, total CVD mortality at lag 0-10 days and YLL at lag 0-8 days increased 2.26% (95% confidence interval (CI): 0.85-3.69%) and 23.24 (6.07-40.42) person years, respectively. Corresponding increases were 3.45% (1.44-5.49%) and 35.21 (10.85-59.58) person years for an IQR rise in PM_2.5mean. Significant associations between PM_2.5 pollution (i.e., PM_2.5mean and PM_2.5DECH) and cause-specific cardiovascular health (i.e., mortality and YLL) were only identified in stroke. Subgroup analyses showed that male and people aged 0-64 years suffered more from PM_2.5 pollution. Furthermore, we attributed a greater CVD burden to PM_2.5DECH (1.67% for mortality and 2.67% for YLL) than PM_2.5mean (0.63% for mortality and 0.70% for YLL) during the study period.

Conclusions: This study strengthened the evidence for the aggravated CVD mortality burden associated with short-term exposure to PM_2.5. Our findings also suggested that PM_2.5DECH might be a potential alternative indicator of exposure assessment in PM_2.5-related health investigations.