Opposing effects of NPM1wt and NPM1c mutants on AKT signaling in AML

Leukemia. 2020 Apr;34(4):1172-1176. doi: 10.1038/s41375-019-0621-7. Epub 2019 Nov 14.

Zhuo Ren¹, Mariusz Shrestha^{2

3}, Takashi Sakamoto⁴, Tali Melkman¹, Li Meng¹, Rob A Cairns⁴, Eldad Zacksenhaus^{2

3

5}, Tak W Mak^{1

4

5}, Vuk Stambolic^{1

5}, Mark D Minden^{6

7}, Jiance Atom Wang^{1

5}

¹ Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
² Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
³ Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
⁴ The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
⁵ Department of Medicine and Medical Biophysics, University of Toronto, Toronto, ON, Canada.
⁶ Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. mark.minden@uhn.ca.
⁷ Department of Medicine and Medical Biophysics, University of Toronto, Toronto, ON, Canada. mark.minden@uhn.ca.

No abstract available

Keywords: AKT Signaling; Acute Myeloid Leukemia (AML); NPM1c Mutation; Nucleophosmin (NPM1); Physical Interaction.

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