Gastric Cancer - From Aetiology to Management: Differences Between the East and the West

W L Chan; K O Lam; V H F Lee; M Davidson; T H So; J S Li; I Chau; D L W Kwong

doi:10.1016/j.clon.2019.05.012

Gastric Cancer - From Aetiology to Management: Differences Between the East and the West

Clin Oncol (R Coll Radiol). 2019 Aug;31(8):570-577. doi: 10.1016/j.clon.2019.05.012. Epub 2019 Jun 7.

Authors

W L Chan¹, K O Lam², V H F Lee³, M Davidson⁴, T H So⁵, J S Li⁶, I Chau⁴, D L W Kwong³

Affiliations

¹ Department of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong. Electronic address: winglok@hku.hk.
² Department of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong; Clinical Oncology Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China. Electronic address: lamkaon@hku.hk.
³ Department of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong; Clinical Oncology Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
⁴ Department of Medicine, Royal Marsden Hospital NHS Foundation Trust, London, UK.
⁵ Department of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.
⁶ Clinical Oncology Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.

PMID: 31178345
DOI: 10.1016/j.clon.2019.05.012

Abstract

Gastric cancers are highly prevalent in both the East and the West, although they differ in aetiology and prognostic outcome. Management of gastric cancer from screening to definitive treatment varies substantially between Eastern and Western countries and regions, owing to numerous factors, including government incentives to carry out population-wide screening programmes to detect early disease, differences in clinical and biological tumour behaviours and responsiveness to treatment, patient accessibility to effective treatment, etc. This review highlights and contrasts the differences in tumour aetiology and histology, as well as the management approaches between the East and the West, which gives important insights and inspirations on future international multicentre research collaboration to combat this dreadful malignancy.

Keywords: Aetiology; chemotherapy; gastric cancer; radiation therapy; surgery; targeted therapy.

Publication types

Review

MeSH terms

Humans
Prognosis
Stomach Neoplasms* / epidemiology
Stomach Neoplasms* / etiology
Stomach Neoplasms* / pathology
Stomach Neoplasms* / therapy