Breakthrough Moments: Organoid Models of Cancer

April S Chan; Helen H N Yan; Suet Yi Leung

doi:10.1016/j.stem.2019.05.006

Breakthrough Moments: Organoid Models of Cancer

Cell Stem Cell. 2019 Jun 6;24(6):839-840. doi: 10.1016/j.stem.2019.05.006.

Authors

April S Chan¹, Helen H N Yan², Suet Yi Leung³

Affiliations

¹ Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
² Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong. Electronic address: yanhelen@hku.hk.
³ Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong; The Jockey Club Centre for Clinical Innovation and Discovery, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong. Electronic address: suetyi@hku.hk.

PMID: 31173712
DOI: 10.1016/j.stem.2019.05.006

Abstract

Five years ago, Li et al. (2014) and Gao et al. (2014) reported the power and unique advantages of cancer organoids. We shine a spotlight on the platform's enormous potential for studying cancer biology and as a preclinical human tumor model that can facilitate drug discovery and personalized therapy.

MeSH terms

Animals
Cell Culture Techniques
Disease Models, Animal
Drug Discovery
Humans
Neoplasms / pathology*
Neoplasms, Experimental / pathology*
Organoids / pathology*
Precision Medicine
Xenograft Model Antitumor Assays