Abstract
Endothelium-dependent contractions of isolated veins can be induced with arachidonic acid and thrombin. Anoxia causes endothelium-dependent contractions in a variety of isolated arteries and veins. Rapid stretch and acetylcholine contract cerebral arteries with, but not those without endothelium. Acetylcholine (and serotonin) cause endothelium-dependent contractions in the aorta of the spontaneously hypertensive, but not that of the normotensive rat.
MeSH terms
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Acetylcholine / pharmacology
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Animals
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Arachidonic Acid
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Arachidonic Acids / pharmacology
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Arteries / drug effects
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Arteries / physiology*
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Dogs
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Endothelium / drug effects
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Endothelium / physiology
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Hypoxia / physiopathology
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Physical Stimulation
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Rats
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Rats, Inbred SHR
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Serotonin / pharmacology
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Thrombin / pharmacology
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Vasoconstriction*
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Vasodilation
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Veins / drug effects
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Veins / physiology*
Substances
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Arachidonic Acids
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Arachidonic Acid
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Serotonin
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Thrombin
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Acetylcholine