Endothelium-dependent contractions in arteries and veins

Blood Vessels. 1987;24(3):141-4. doi: 10.1159/000158688.

Abstract

Endothelium-dependent contractions of isolated veins can be induced with arachidonic acid and thrombin. Anoxia causes endothelium-dependent contractions in a variety of isolated arteries and veins. Rapid stretch and acetylcholine contract cerebral arteries with, but not those without endothelium. Acetylcholine (and serotonin) cause endothelium-dependent contractions in the aorta of the spontaneously hypertensive, but not that of the normotensive rat.

MeSH terms

  • Acetylcholine / pharmacology
  • Animals
  • Arachidonic Acid
  • Arachidonic Acids / pharmacology
  • Arteries / drug effects
  • Arteries / physiology*
  • Dogs
  • Endothelium / drug effects
  • Endothelium / physiology
  • Hypoxia / physiopathology
  • Physical Stimulation
  • Rats
  • Rats, Inbred SHR
  • Serotonin / pharmacology
  • Thrombin / pharmacology
  • Vasoconstriction*
  • Vasodilation
  • Veins / drug effects
  • Veins / physiology*

Substances

  • Arachidonic Acids
  • Arachidonic Acid
  • Serotonin
  • Thrombin
  • Acetylcholine