A long non-coding RNA LINC01288 facilitates non-small cell lung cancer progression through stabilizing IL-6 mRNA

Biochem Biophys Res Commun. 2019 Jun 25;514(2):443-449. doi: 10.1016/j.bbrc.2019.04.132. Epub 2019 May 1.

Abstract

The non-small cell lung cancer (NSCLC) denotes a malignant type of cancers. Long non-coding RNAs (lncRNAs) can actively participate in cancer development. However, the exact role of lncRNAs in NSCLC remains largely elusive. In current work, we report a novel intergenic lncRNA LINC01288 involved in NSCLC. We found that LINC01288 is frequently upregulated in NSCLC samples and cell lines. LINC01288 significantly promotes viability, migration, xenograft tumor growth and metastasis in vitro and in vivo. LINC01288 physically interacts with the IL-6 mRNA and increase the stability of IL-6 transcripts. Subsequently, the autocrine induction of IL-6 and enhanced STAT3 activation may facilitate NSCLC progression. Collectively, our data have demonstrated that LINC01288 serves as a crucial mediator of IL-6/STAT3 pathway and created novel interplay between lncRNAs and tumor development.

Keywords: IL-6; LINC01288; NSCLC; lncRNA.

MeSH terms

  • Animals
  • Autocrine Communication
  • Carcinogenesis / genetics
  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Carcinoma, Non-Small-Cell Lung / metabolism
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Cell Line
  • Disease Progression*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Interleukin-6 / genetics*
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology
  • Mice
  • RNA Stability / genetics*
  • RNA, Long Noncoding / genetics*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • STAT3 Transcription Factor / metabolism
  • Xenograft Model Antitumor Assays

Substances

  • Interleukin-6
  • RNA, Long Noncoding
  • RNA, Messenger
  • STAT3 Transcription Factor
  • STAT3 protein, human