LMO7 deficiency reveals the significance of the cuticular plate for hearing function

Nat Commun. 2019 Mar 8;10(1):1117. doi: 10.1038/s41467-019-09074-4.

Abstract

Sensory hair cells, the mechanoreceptors of the auditory and vestibular systems, harbor two specialized elaborations of the apical surface, the hair bundle and the cuticular plate. In contrast to the extensively studied mechanosensory hair bundle, the cuticular plate is not as well understood. It is believed to provide a rigid foundation for stereocilia motion, but specifics about its function, especially the significance of its integrity for long-term maintenance of hair cell mechanotransduction, are not known. We discovered that a hair cell protein called LIM only protein 7 (LMO7) is specifically localized in the cuticular plate and the cell junction. Lmo7 KO mice suffer multiple cuticular plate deficiencies, including reduced filamentous actin density and abnormal stereociliar rootlets. In addition to the cuticular plate defects, older Lmo7 KO mice develop abnormalities in inner hair cell stereocilia. Together, these defects affect cochlear tuning and sensitivity and give rise to late-onset progressive hearing loss.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Actins / metabolism
  • Animals
  • Cochlea / physiology
  • Disease Models, Animal
  • Hair Cells, Auditory / physiology*
  • Hair Cells, Auditory / ultrastructure
  • Hair Cells, Auditory, Inner / physiology
  • Hair Cells, Auditory, Inner / ultrastructure
  • Hearing / genetics
  • Hearing / physiology*
  • Hearing Loss / etiology
  • Hearing Loss / genetics
  • Hearing Loss / physiopathology
  • LIM Domain Proteins / deficiency*
  • LIM Domain Proteins / genetics
  • LIM Domain Proteins / physiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Mice, Knockout
  • Microscopy, Electron, Scanning
  • Stereocilia / genetics
  • Stereocilia / physiology
  • Stereocilia / ultrastructure
  • Transcription Factors / deficiency*
  • Transcription Factors / genetics
  • Transcription Factors / physiology

Substances

  • Actins
  • LIM Domain Proteins
  • Lmo7 protein, mouse
  • Transcription Factors