Models of Parkinson's Disease with Special Emphasis on Drosophila melanogaster

Ambreen Fatima; Smita Jyoti; Yasir Hasan Siddique

doi:10.2174/1871527317666180820164250

Models of Parkinson's Disease with Special Emphasis on Drosophila melanogaster

CNS Neurol Disord Drug Targets. 2018;17(10):757-766. doi: 10.2174/1871527317666180820164250.

Authors

Ambreen Fatima¹, Smita Jyoti¹, Yasir Hasan Siddique¹

Affiliation

¹ Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India.

PMID: 30129420
DOI: 10.2174/1871527317666180820164250

Abstract

Background & objective: Parkinson's disease is the second most common neurodegenerative disorder affecting more than 1% of the population averaged 60 years of age. The majority of PD cases are sporadic and are probably caused by a combination of risk factors but 5-10% of the PD cases are familial. Due to the high degree of the gene, conservation in humans, mice and insects using an animal model system is a valuable approach to further elucidate the roles of the genes in PD.

Conclusion: The present review highlights the models used to study PD symptoms with special emphasis on Drosophila.

Keywords: Drosophila; Parkinson's disease; etiology; models; neurdegerative disorder; pathological..

Publication types

Review

MeSH terms

Animals
Animals, Genetically Modified
Disease Models, Animal*
Drosophila melanogaster
Humans
Parkinson Disease / etiology*
Parkinson Disease / genetics*