Characteristics and distribution of beta thalassemia haplotypes in South China

Hum Genet. 1986 May;73(1):23-6. doi: 10.1007/BF00292658.

Abstract

Eleven restriction site polymorphisms in the beta-globin gene cluster were determined in 48 Chinese with homozygous beta-thalassemia and their parents. Seven haplotypes were identified as associated with the beta thal chromosome and 25 with the beta A chromosome. The distribution of the various beta thal haplotypes in different regions of South China was mapped and discussed in relation to prenatal diagnosis and migration of the Chinese people.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • China / ethnology
  • Chromosome Mapping
  • Chromosomes, Human, 6-12 and X
  • DNA Restriction Enzymes
  • Female
  • Genetic Linkage
  • Globins / genetics*
  • Homozygote
  • Hong Kong
  • Humans
  • Polymorphism, Genetic
  • Pregnancy
  • Prenatal Diagnosis
  • Thalassemia / genetics*

Substances

  • Globins
  • DNA Restriction Enzymes