Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population

Asian J Androl. 2018 Jul-Aug;20(4):324-329. doi: 10.4103/aja.aja_81_17.

Abstract

This study was performed to evaluate prostate-specific antigen-age volume (PSA-AV) scores in predicting prostate cancer (PCa) in a Chinese biopsy population. A total of 2355 men who underwent initial prostate biopsy from January 2006 to November 2015 in Huashan Hospital were recruited in the current study. The PSA-AV scores were calculated and assessed together with PSA and PSA density (PSAD) retrospectively. Among 2133 patients included in the analysis, 947 (44.4%) were diagnosed with PCa. The mean age, PSA, and positive rates of digital rectal examination result and transrectal ultrasound result were statistically higher in men diagnosed with PCa (all P < 0.05). The values of area under the receiver operating characteristic curves (AUCs) of PSAD and PSA-AV were 0.864 and 0.851, respectively, in predicting PCa in the entire population, both performed better than PSA (AUC = 0.805; P < 0.05). The superiority of PSAD and PSA-AV was more obvious in subgroup with PSA ranging from 2.0 ng ml-1 to 20.0 ng ml-1. A PSA-AV score of 400 had a sensitivity and specificity of 93.7% and 40.0%, respectively. In conclusion, the PSA-AV score performed equally with PSAD and was better than PSA in predicting PCa. This indicated that PSA-AV score could be a useful tool for predicting PCa in Chinese population.

Keywords: China; age; prostate cancer; prostate-specific antigen; volume.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / pathology*
  • Area Under Curve
  • Asian People
  • Digital Rectal Examination
  • Humans
  • Image-Guided Biopsy
  • Male
  • Predictive Value of Tests
  • Prostate-Specific Antigen / blood*
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / diagnostic imaging
  • ROC Curve
  • Reference Values
  • Retrospective Studies
  • Sensitivity and Specificity
  • Ultrasonography, Interventional

Substances

  • Prostate-Specific Antigen