Impact of DNA repair, folate and glutathione gene polymorphisms on risk of non small cell lung cancer

Pathol Res Pract. 2018 Jan;214(1):44-52. doi: 10.1016/j.prp.2017.11.015. Epub 2017 Nov 21.

Abstract

Lung cancer, particularly non-small cell lung cancer (NSCLC) subtype, is the leading cause of cancer-related death related worldwide. Numerous gene polymorphisms in DNA repair, folate and glutathione pathways have been associated with susceptibility of NSCLC. We conducted this study to evaluate the effects of ERCC1, ERCC2, ERCC5, XRCC1, XRCC3, MTHFR, MTR, MTHFD1, SLC19A1 and GSTP1 gene polymorphisms on risk of NSCLC. No association between these gene polymorphisms and susceptibility of NSCLC were found in our patients, suggesting that genetic variations in genes involved in DNA repair, folate and glutathione metabolism pathways may not influence the risk of NSCLC.

Keywords: DNA repair pathway; Folate metabolism pathway; Glutathione metabolism pathway; Non-small cell lung cancer; Polymorphisms; Risk.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Carcinoma, Non-Small-Cell Lung / genetics*
  • DNA Damage* / genetics
  • DNA Repair / genetics*
  • Female
  • Genotype
  • Glutathione / genetics*
  • Humans
  • Lung Neoplasms / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Risk

Substances

  • Glutathione