Genetic polymorphism of natural Epstein-Barr virus isolates from infectious mononucleosis patients and healthy carriers

J Virol. 1988 Oct;62(10):3862-6. doi: 10.1128/JVI.62.10.3862-3866.1988.

Abstract

We analyzed Epstein-Barr virus (EBV) genomes from lymphoblastoid cell lines isolated from patients with infectious mononucleosis and from healthy subjects from California, Hawaii, and Hong Kong between 1970 and 1987. Using genetic polymorphism as epidemiological markers, we found that several genotypes of EBV cocirculate in a community and that although most EBV strains isolated from California and Southern China may be differentiated genotypically, there was no specific association between genotype and disease or time of isolation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • B-Lymphocytes / microbiology
  • California
  • Carrier State / microbiology*
  • Cell Line
  • DNA Restriction Enzymes
  • DNA, Viral / analysis
  • Genotype
  • Hawaii
  • Herpesvirus 4, Human / genetics*
  • Hong Kong
  • Humans
  • Infectious Mononucleosis / microbiology*
  • Lymphocyte Activation
  • Nucleic Acid Hybridization
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length*

Substances

  • DNA, Viral
  • DNA Restriction Enzymes