Primary hyperparathyroidism
Med Clin (Barc). 2018 Mar 23;150(6):226-232.
doi: 10.1016/j.medcli.2017.07.020.
Epub 2017 Oct 6.
[Article in
English,
Spanish]
Affiliations
- 1 Unidad de Metabolismo Óseo, Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario Campus de la Salud, Instituto de Investigación Biosanitaria de Granada, Granada, España; Departamento de Medicina, Universidad de Granada, Granada, España. Electronic address: mmt@mamuto.es.
- 2 Unidad de Metabolismo Óseo, Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario Campus de la Salud, Instituto de Investigación Biosanitaria de Granada, Granada, España; Departamento de Medicina, Universidad de Granada, Granada, España.
Abstract
Primary hyperparathyroidism (PHPT) is a common endocrinological process, characterized by chronic elevation of serum concentrations of calcium and parathyroid hormone (PTH). Many years ago, the most frequent forms of clinical presentation were symptomatic renal or skeletal disease with moderate or severe hypercalcemia; however, currently, most patients have few symptoms and mild hypercalcemia. A new form of presentation called normocalcemic PHPT has also been described but clinical consequences are not well established. The biochemical profile of PHPT is characterized by hypercalcemia and high or inappropriately normal PTH concentrations. Parathyroidectomy is the only definitive cure. Medical treatment with the calcimimetic cinacalcet has been shown to normalize calcemia in a high percentage of cases.
Keywords:
Cinacalcet; Hiperparatiroidismo primario; Hormona paratiroidea; Parathyroid hormone; Primary hyperparathyroidism.
Copyright © 2017 Elsevier España, S.L.U. All rights reserved.
MeSH terms
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Biomarkers / blood
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Calcium / blood
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Calcium-Regulating Hormones and Agents / therapeutic use
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Cinacalcet / therapeutic use
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Diagnosis, Differential
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Humans
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Hyperparathyroidism, Primary* / blood
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Hyperparathyroidism, Primary* / diagnosis
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Hyperparathyroidism, Primary* / etiology
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Hyperparathyroidism, Primary* / therapy
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Parathyroid Hormone / blood
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Parathyroidectomy
Substances
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Biomarkers
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Calcium-Regulating Hormones and Agents
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Parathyroid Hormone
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Calcium
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Cinacalcet