Linkage of DNA probe B79a (D7S13) to cystic fibrosis

B J Wainwright; L C Tsui; M Leppert; M Buchwald; X Estivill; P O'Connell; M Lathrop; J M Lalouel; R White; R Williamson

Linkage of DNA probe B79a (D7S13) to cystic fibrosis

Am J Hum Genet. 1987 Nov;41(5):944-7.

Authors

B J Wainwright¹, L C Tsui, M Leppert, M Buchwald, X Estivill, P O'Connell, M Lathrop, J M Lalouel, R White, R Williamson, et al.

Affiliation

¹ Department of Biochemistry, St. Mary's Hospital Medical School, University of London, England.

PMID: 2890297
PMCID: PMC1684343

Abstract

We have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at theta = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Cystic Fibrosis / genetics*
DNA / genetics*
Genetic Linkage*
Genetic Markers*
Humans
Polymorphism, Restriction Fragment Length

Substances

Genetic Markers
DNA