Review of the role of the sentinel node biopsy in neoadjuvant chemotherapy in women with breast cancer and negative or positive axillary node at diagnosis

Rev Esp Med Nucl Imagen Mol (Engl Ed). 2018 Jan-Feb;37(1):63-70. doi: 10.1016/j.remn.2017.06.007. Epub 2017 Aug 30.
[Article in English, Spanish]

Abstract

The role of the selective sentinel node biopsy (SNB) is increasing in relevance in breast cancer women with indication of neoadjuvant chemotherapy (NAC). The Radiosurgery Working Group of the SEMNIM is aware of the necessity of establishing the need for SNB before or after NAC, and also how to manage patients with axillary node-negative or node-positive. There is sufficient data to assess that the SNB with radioisotope techniques are feasible and safe in all these scenarios. An adequate axilla evaluation prior to surgery and the possibility of marking prior to NAC the nodes infiltrated must be the two main pillars to guarantee the success of the SNB. It has been shown that to incorporate the SNB in breast cancer women with indication of NAC increases the rate of a conservative treatment of the axilla that will be a clear benefit for these patients.

Keywords: Breast cancer; Cáncer de mama; Ganglio centinela; Neoadjuvant chemotherapy; Quimioterapia neoadyuvante; Sentinel node.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Axilla
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / surgery
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Female
  • Humans
  • Lymph Node Excision
  • Lymphatic Metastasis / diagnostic imaging*
  • Mastectomy
  • Multicenter Studies as Topic
  • Neoadjuvant Therapy*
  • Sentinel Lymph Node Biopsy* / methods
  • Unnecessary Procedures