First report of NDM-1-producing clinical isolate of Leclercia adecarboxylata in Spain

Diagn Microbiol Infect Dis. 2017 Jul;88(3):268-270. doi: 10.1016/j.diagmicrobio.2017.04.013. Epub 2017 May 3.

Abstract

We describe the case of NDM-1-producing Leclercia adecarboxylata recovered from the clinical sample of a patient hospitalized for a trauma-related injury to his foot. The isolate was resistant to all beta-lactams, quinolones, trimetroprim-sulfametoxazol, gentamicin and tobramicyn. The blaNDM-1 gene was located in a conjugative plasmid that also contained the blaSHV-12 gene and was preceded by a disrupted insertion sequence of ISAba125. The plasmid belongs to the incompatibility group X3, which is known to be an important vector for NDM-1 dissemination in China. This is the first reported case of NDM-1L. adecarboxylata in our country and evidences that species of uncertain clinical relevance can act as hidden sources of clinically important resistance determinants.

Keywords: China; Inc.-X3; L. adecarboxilata; NDM-1; Spain.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology
  • China
  • Conjugation, Genetic
  • DNA Transposable Elements
  • Drug Resistance, Multiple, Bacterial
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / enzymology*
  • Enterobacteriaceae / genetics
  • Enterobacteriaceae / isolation & purification*
  • Enterobacteriaceae Infections / microbiology*
  • Foot Injuries / complications
  • Humans
  • Male
  • Plasmids / analysis
  • Plasmids / classification
  • Spain
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • DNA Transposable Elements
  • beta-Lactamases
  • beta-lactamase NDM-1