Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress

Assaf Ramot; Zhiying Jiang; Jin-Bin Tian; Tali Nahum; Yael Kuperman; Nicholas Justice; Alon Chen

doi:10.1038/nn.4491

Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress

Nat Neurosci. 2017 Mar;20(3):385-388. doi: 10.1038/nn.4491. Epub 2017 Jan 30.

Authors

Assaf Ramot^{1

2}, Zhiying Jiang³, Jin-Bin Tian⁴, Tali Nahum^{1

2}, Yael Kuperman⁵, Nicholas Justice³, Alon Chen^{1

2}

Affiliations

¹ Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
² Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
³ Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, Texas, USA.
⁴ Department of Integrative Biology and Pharmacology, University of Texas Health Sciences Center, Houston, Texas, USA.
⁵ Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.

PMID: 28135239
DOI: 10.1038/nn.4491

Abstract

The hypothalamic-pituitary-adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.

MeSH terms

Animals
Corticotropin-Releasing Hormone / pharmacology
Corticotropin-Releasing Hormone / physiology
Cortisone / blood
Hypothalamo-Hypophyseal System / physiology*
Locomotion / physiology
Male
Maze Learning / physiology
Mice
Mice, Knockout
Mice, Transgenic
Paraventricular Hypothalamic Nucleus / physiology*
Pituitary-Adrenal System / physiology*
Receptors, Corticotropin-Releasing Hormone / genetics
Receptors, Corticotropin-Releasing Hormone / physiology*
Stress, Physiological / physiology*
Stress, Psychological / physiopathology*

Substances

Receptors, Corticotropin-Releasing Hormone
CRF receptor type 1
Corticotropin-Releasing Hormone
Cortisone