In Vitro Activity of Posaconazole against Talaromyces marneffei by Broth Microdilution and Etest Methods and Comparison to Itraconazole, Voriconazole, and Anidulafungin

Antimicrob Agents Chemother. 2017 Feb 23;61(3):e01480-16. doi: 10.1128/AAC.01480-16. Print 2017 Mar.

Abstract

We determined the susceptibilities of 57 Talaromyces marneffei strains to anidulafungin, itraconazole, voriconazole, and posaconazole with MICs of 2 to 8, 0.002 to 0.004, 0.016 to 0.063, and 0.001 to 0.002 μg/ml by broth microdilution and >32, ≤0.002 to 0.008, ≤0.002 to 0.008, and ≤0.002 μg/ml by Etest, respectively, at yeast phase; MICs at mycelial phase for anidulafungin and posaconazole were 1 to 2 and 0.004 to 0.063 μg/ml, respectively. The results suggest promising activities of posaconazole. Etest can be used for testing of azoles against T. marneffei.

Keywords: Etest; Penicillium; Talaromyces marneffei; anidulafungin; itraconazole; posaconazole; susceptibility; voriconazole.

Publication types

  • Comparative Study

MeSH terms

  • Anidulafungin
  • Antifungal Agents / pharmacology*
  • Disk Diffusion Antimicrobial Tests
  • Echinocandins / pharmacology*
  • Humans
  • Itraconazole / pharmacology*
  • Penicillium / drug effects
  • Penicillium / growth & development
  • Reagent Strips
  • Talaromyces / drug effects*
  • Talaromyces / growth & development
  • Talaromyces / isolation & purification
  • Triazoles / pharmacology*
  • Voriconazole / pharmacology*

Substances

  • Antifungal Agents
  • Echinocandins
  • Reagent Strips
  • Triazoles
  • Itraconazole
  • posaconazole
  • Anidulafungin
  • Voriconazole