RBPJ is the central transcription factor that controls the Notch-dependent transcriptional response by coordinating repressing histone H3K27 deacetylation and activating histone H3K4 methylation. Here, we discuss the molecular mechanisms how RBPJ interacts with opposing NCoR/HDAC-corepressing or KMT2D/UTX-coactivating complexes and how this is controlled by phosphorylation of chromatin modifiers.
Keywords: KMT2D; NCoR; NICD; Notch; RBPJ; SHARP; casein kinase 2; chromatin; transcription; transcriptional activation; transcriptional repression.