Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research

Michael M Engelgau; Emmanuel Peprah; Uchechukwu K A Sampson; Helena Mishoe; Ivor J Benjamin; Pamela S Douglas; Judith S Hochman; Paul M Ridker; Neal Brandes; William Checkley; Sameh El-Saharty; Majid Ezzati; Anselm Hennis; Lixin Jiang; Harlan M Krumholz; Gabrielle Lamourelle; Julie Makani; K M Venkat Narayan; Kwaku Ohene-Frempong; Sharon E Straus; David Stuckler; David A Chambers; Deshirée Belis; Glen C Bennett; Josephine E Boyington; Tony L Creazzo; Janet M de Jesus; Chitra Krishnamurti; Mia R Lowden; Antonello Punturieri; Susan T Shero; Neal S Young; Shimian Zou; George A Mensah

doi:10.1016/j.gheart.2016.03.640

Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research

Glob Heart. 2017 Dec;12(4):341-348. doi: 10.1016/j.gheart.2016.03.640. Epub 2016 Jul 21.

Authors

Michael M Engelgau¹, Emmanuel Peprah², Uchechukwu K A Sampson², Helena Mishoe², Ivor J Benjamin³, Pamela S Douglas⁴, Judith S Hochman⁵, Paul M Ridker⁶, Neal Brandes⁷, William Checkley⁸, Sameh El-Saharty⁹, Majid Ezzati¹⁰, Anselm Hennis¹¹, Lixin Jiang¹², Harlan M Krumholz¹³, Gabrielle Lamourelle¹⁴, Julie Makani¹⁵, K M Venkat Narayan¹⁶, Kwaku Ohene-Frempong¹⁷, Sharon E Straus¹⁸, David Stuckler¹⁹, David A Chambers²⁰, Deshirée Belis², Glen C Bennett², Josephine E Boyington²¹, Tony L Creazzo²², Janet M de Jesus², Chitra Krishnamurti², Mia R Lowden²³, Antonello Punturieri²⁴, Susan T Shero², Neal S Young²⁵, Shimian Zou²⁶, George A Mensah²

Affiliations

¹ Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: michael.engelgau@nih.gov.
² Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
³ Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
⁴ Duke Clinical Research Institute, Duke University, Durham, NC, USA.
⁵ New York University-Health and Hospitals Corporation Clinical and Translational Institute, New York University School of Medicine, New York, NY, USA.
⁶ Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁷ Implementation Research and Delivery Science Task Force, U.S. Agency for International Development, Washington, DC, USA.
⁸ Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
⁹ South Asia Region, the World Bank, Washington, DC, USA.
¹⁰ Medical Research Council-Public Health England Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.
¹¹ Pan American Health Organization/World Health Organization, Washington, DC, USA.
¹² National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
¹³ Cardiovascular Medicine, the Robert Wood Johnson Foundation Clinical Scholars Program, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
¹⁴ Office of Global Affairs at U.S. Department of Health and Human Services, Washington, DC, USA.
¹⁵ Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
¹⁶ Department of Global Health, Emory University, Atlanta, GA, USA.
¹⁷ Comprehensive Sickle Cell Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
¹⁸ Internal and Geriatric Medicine, University of Toronto, Toronto, Ontario, Canada.
¹⁹ Department of Sociology, University of Oxford, Oxford, United Kingdom.
²⁰ Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
²¹ Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
²² Office of Scientific Review, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
²³ Office of Strategic Planning, Initiative Development, and Analysis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
²⁴ Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
²⁵ Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
²⁶ Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

PMID: 27452772
DOI: 10.1016/j.gheart.2016.03.640

Abstract

Almost three-quarters (74%) of all the noncommunicable disease burden is found within low- and middle-income countries. In September 2014, the National Heart, Lung, and Blood Institute held a Global Health Think Tank meeting to obtain expert advice and recommendations for addressing compelling scientific questions for late stage (T4) research-research that studies implementation strategies for proven effective interventions-to inform and guide the National Heart, Lung, and Blood Institute's global health research and training efforts. Major themes emerged in two broad categories: 1) developing research capacity; and 2) efficiently defining compelling scientific questions within the local context. Compelling scientific questions included how to deliver inexpensive, scalable, and sustainable interventions using alternative health delivery models that leverage existing human capital, technologies and therapeutics, and entrepreneurial strategies. These broad themes provide perspectives that inform an overarching strategy needed to reduce the heart, lung, blood, and sleep disorders disease burden and global health disparities.

Published by Elsevier B.V.

Publication types

Review

MeSH terms

Congresses as Topic
Disease Management*
Global Health
Guidelines as Topic*
Humans
Morbidity / trends
Noncommunicable Diseases / epidemiology
Noncommunicable Diseases / therapy*
Translational Research, Biomedical / methods*

Abstract

Publication types

MeSH terms

Grants and funding