A Supramolecular Shear-Thinning Anti-Inflammatory Steroid Hydrogel

Qian Liu; Changyou Zhan; Aoune Barhoumi; Weiping Wang; Claudia Santamaria; James Brian McAlvin; Daniel S Kohane

doi:10.1002/adma.201601147

A Supramolecular Shear-Thinning Anti-Inflammatory Steroid Hydrogel

Adv Mater. 2016 Aug;28(31):6680-6. doi: 10.1002/adma.201601147. Epub 2016 May 23.

Authors

Qian Liu¹, Changyou Zhan¹, Aoune Barhoumi¹, Weiping Wang¹, Claudia Santamaria¹, James Brian McAlvin¹, Daniel S Kohane¹

Affiliation

¹ Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.

PMID: 27214390
DOI: 10.1002/adma.201601147

Abstract

Shear-thinning and self-healing steroid-drug-based hydrogels are presented, which exhibit rapid and complete recovery of their mechanical properties within seconds following stress-induced flow. The hydrogels release steroid drug in vivo with no visible residue when release is complete.

Keywords: shear-thinning; steroid drugs; supramolecular hydrogels.