Serosal involvement in IgG4-related disease: report of two cases and review of the literature

Rheumatol Int. 2016 Jul;36(7):1033-41. doi: 10.1007/s00296-016-3501-8. Epub 2016 May 20.

Abstract

IgG4-related disease (IgG4-RD) is a recently described entity characterized by lymphoplasmacytic infiltrates, usually mimicking tumors, affecting almost every organ or system. Nevertheless, serosal involvement has been rarely reported. In this article, we report two cases of IgG4-RD with serosal involvement and review the literature. Because of the varied clinical pictures found in our review, we suggest a new terminology for the description of IgG4-RD with serosal involvement.

Keywords: IgG4-related disease; Pericardium; Peritoneum; Pleura.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / drug therapy
  • Autoimmune Diseases / immunology*
  • Biomarkers / blood
  • Drug Therapy, Combination
  • Female
  • Humans
  • Immunoglobulin G / blood*
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Middle Aged
  • Pericardial Effusion / diagnosis
  • Pericardial Effusion / drug therapy
  • Pericardial Effusion / immunology*
  • Pericardium / diagnostic imaging
  • Pericardium / immunology*
  • Pleura / diagnostic imaging
  • Pleura / immunology*
  • Pleural Effusion / diagnosis
  • Pleural Effusion / drug therapy
  • Pleural Effusion / immunology*
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Biomarkers
  • Immunoglobulin G
  • Immunosuppressive Agents