Engineering Coronaviruses to Evaluate Emergence and Pathogenic Potential

Trends Microbiol. 2016 Jun;24(6):427-429. doi: 10.1016/j.tim.2016.04.001. Epub 2016 Apr 16.

Abstract

A recent study provides a platform for generating infectious coronavirus genomes using sequence data, examining their capabilities of replicating in human cells and causing diseases in animal models, and evaluating therapeutics and vaccines. Similar approaches could be used to assess the potential of human emergence and pathogenicity for other viruses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Communicable Diseases, Emerging / genetics
  • Coronavirus / drug effects
  • Coronavirus / genetics*
  • Coronavirus / pathogenicity*
  • Coronavirus Infections / diet therapy
  • Coronavirus Infections / prevention & control
  • Coronavirus Infections / virology*
  • DNA, Viral
  • Disease Models, Animal
  • Genetic Engineering*
  • Genome, Viral
  • Humans
  • Recombination, Genetic

Substances

  • DNA, Viral