Objectives: Our objective was to estimate the incidence of influenza-associated hospitalizations and in-hospital deaths in Central American Region.
Design and setting: We used hospital discharge records, influenza surveillance virology data, and population projections collected from Costa Rica, El Salvador, Guatemala, Honduras, and Nicaragua to estimate influenza-associated hospitalizations and in-hospital deaths. We performed a meta-analysis of influenza-associated hospitalizations and in-hospital deaths.
Main outcome measures: The highest annual incidence was observed among children aged <5 years (136 influenza-associated hospitalizations per 100 000 persons).
Results: Annually, 7 625-11 289 influenza-associated hospitalizations and 352-594 deaths occurred in the subregion.
Conclusions: Our results suggest that a substantive number of persons are annually hospitalized because of influenza. Health officials should estimate how many illnesses could be averted through increased influenza vaccination.
Keywords: America; burden of disease; hospitalizations; influenza; meta-analysis; mortality; multiplier model.
© 2016 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.