Prevention of secondary caries by silver diamine fluoride

Int Dent J. 2016 Apr;66(2):71-7. doi: 10.1111/idj.12207. Epub 2015 Dec 22.

Abstract

Purpose: This study aimed to investigate the use of 38% silver diamine fluoride (SDF) as a treatment for preventing secondary caries in glass ionomer cement (GIC) and composite resin (CR) restorations.

Methods: Six extracted human sound premolars were collected. Four cavities (4 × 2 × 2 mm(3) ) were prepared on each premolar and then allocated to the following restoration groups: group 1, SDF conditioning and GIC restoration; group 2, GIC restoration; group 3, SDF conditioning and CR restoration; and group 4, CR restoration. After thermal cycling and sterilisation, the teeth were soaked in a 5% sucrose solution containing Streptococcus mutans and Lactobacillus acidophilus for 28 days. Micro-computed tomography was used to study demineralisation. The outer lesion depth (OLD) and wall lesion depth (WLD) of the tooth-restoration interface were measured. The OLD and WLD were directly related to the extent of secondary caries. Two-way analysis of variance was used to analyse the effects of SDF conditioning and restorative materials on OLD.

Results: The mean ± standard deviation OLD values were 156 ± 45 μm, 235 ± 33 μm, 153 ± 20 μm and 232 ± 24 μm for groups 1-4, respectively. The OLD was less in restorations with SDF conditioning (P < 0.001) than in those without SDF conditioning. No interaction effect on OLD was found between the restorative materials and SDF conditioning (P = 0.062). The WLD was detected only in groups 3 and 4.

Clinical significance: Conditioning with 38% SDF can increase resistance of GIC and CR restorations to secondary caries.

Keywords: Silver diamine fluoride; glass ionomer; resin composite; secondary caries.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Cariogenic Agents / adverse effects
  • Cariostatic Agents / therapeutic use*
  • Composite Resins / chemistry
  • Dental Caries / etiology
  • Dental Caries / prevention & control*
  • Dental Cavity Preparation / methods
  • Dental Enamel / drug effects
  • Dental Materials / chemistry
  • Dental Restoration, Permanent / methods*
  • Dentin / drug effects
  • Fluorides, Topical
  • Glass Ionomer Cements / chemistry
  • Humans
  • Imaging, Three-Dimensional / methods
  • In Vitro Techniques
  • Lactobacillus acidophilus / physiology
  • Quaternary Ammonium Compounds / therapeutic use*
  • Random Allocation
  • Recurrence
  • Silver Compounds
  • Streptococcus mutans / physiology
  • Sucrose / adverse effects
  • Temperature
  • Time Factors
  • Tooth Demineralization / etiology
  • X-Ray Microtomography / methods

Substances

  • Cariogenic Agents
  • Cariostatic Agents
  • Composite Resins
  • Dental Materials
  • Fluorides, Topical
  • Glass Ionomer Cements
  • Quaternary Ammonium Compounds
  • Silver Compounds
  • Sucrose
  • silver diamine fluoride