Impaired Frontal-Basal Ganglia Connectivity in Male Adolescents with Conduct Disorder

Jibiao Zhang; Baojuan Li; Junling Gao; Huqing Shi; Xiang Wang; Yali Jiang; Qingsen Ming; Yidian Gao; Ren Ma; Shuqiao Yao

doi:10.1371/journal.pone.0145011

Impaired Frontal-Basal Ganglia Connectivity in Male Adolescents with Conduct Disorder

PLoS One. 2015 Dec 14;10(12):e0145011. doi: 10.1371/journal.pone.0145011. eCollection 2015.

Authors

Jibiao Zhang^{1

2}, Baojuan Li³, Junling Gao⁴, Huqing Shi⁵, Xiang Wang², Yali Jiang², Qingsen Ming², Yidian Gao², Ren Ma², Shuqiao Yao^{2

6}

Affiliations

¹ Department of Psychology, School of Education, Jianghan University, Wuhan, Hubei, China.
² Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
³ School of Biomedical Engineering, Fourth Military Medical University, Xi'an, Shaanxi, China.
⁴ Centre of Buddhist Studies, University of Hong Kong, Hong Kong, China.
⁵ Department of Psychology, Shanghai Normal University, Shanghai, China.
⁶ National Technology Institute of Psychiatry, Changsha, Hunan, China.

Abstract

Alack of inhibition control has been found in subjects with conduct disorder (CD), but the underlying neuropathophysiology remains poorly understood. The current study investigated the different mechanism of inhibition control in adolescent-onset CD males (n = 29) and well-matched healthy controls (HCs) (n = 40) when performing a GoStop task by functional magnetic resonance images. Effective connectivity (EC) within the inhibition control network was analyzed using a stochastic dynamic causality model. We found that EC within the inhibition control network was significantly different in the CD group when compared to the HCs. Exploratory relationship analysis revealed significant negative associations between EC between the IFG and striatum and behavioral scale scores in the CD group. These results suggest for the first time that the failure of inhibition control in subjects with CD might be associated with aberrant connectivity of the frontal-basal ganglia pathways, especially between the IFG and striatum.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Behavior
Brain / diagnostic imaging
Brain / physiopathology*
Brain Mapping
Case-Control Studies
Conduct Disorder / diagnostic imaging
Conduct Disorder / physiopathology*
Humans
Magnetic Resonance Imaging
Male
Neural Pathways
Radiography

Grants and funding

This study was supported by grants from the National Key Technologies R&D Program of China's 11th 5-year Plan grant 2009BAI77B02, National Natural Science Foundation of China (NSFC) grant 81471384, and Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP) grant 20130162110043. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.