We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. In most patients, robust antibody responses developed by the third week of illness. Delayed antibody responses with the neutralization test were associated with more severe disease.
Keywords: MERS; MERS-CoV; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; South Korea; antibody; clinical correlates; coronavirus; diagnostics; humans; immunity; kinetics; seroepidemiologic data; serologic responses; severity; viruses.