Clinical Characteristics, Laboratory Identification, and In Vitro Antifungal Susceptibility of Yarrowia (Candida) lipolytica Isolates Causing Fungemia: a Multicenter, Prospective Surveillance Study

J Clin Microbiol. 2015 Nov;53(11):3639-45. doi: 10.1128/JCM.01985-15. Epub 2015 Aug 26.

Abstract

Our case series showed that uncomplicated Yarrowia lipolytica fungemia might be treated with catheter removal alone. The Vitek 2 YST identification (ID) card system, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), and internal transcribed spacer and 25S nuclear ribosomal DNA (nrDNA) gene sequencing provided reliable identification. All isolates had low MICs to voriconazole, echinocandins, and amphotericin B.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amphotericin B / pharmacology
  • Antifungal Agents / therapeutic use*
  • Base Sequence
  • Catheter-Related Infections / diagnosis*
  • Catheter-Related Infections / drug therapy
  • Catheter-Related Infections / microbiology
  • Catheterization, Central Venous / adverse effects
  • Catheterization, Peripheral / adverse effects
  • Child, Preschool
  • DNA, Ribosomal Spacer / genetics*
  • Echinocandins / pharmacology
  • Female
  • Fungemia / diagnosis*
  • Fungemia / drug therapy*
  • Fungemia / microbiology
  • Hospitalization
  • Humans
  • Infant
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Molecular Sequence Data
  • Prospective Studies
  • Sequence Analysis, DNA
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
  • Voriconazole / pharmacology
  • Yarrowia / drug effects
  • Yarrowia / genetics*

Substances

  • Antifungal Agents
  • DNA, Ribosomal Spacer
  • Echinocandins
  • Amphotericin B
  • Voriconazole