Antiphospholipid syndrome, antiphospholipid antibodies and solid organ transplantation

Lupus. 2015 Nov;24(13):1356-63. doi: 10.1177/0961203315595129. Epub 2015 Jul 9.

Abstract

Antiphospholipid syndrome is considered a high risk factor for any kind of surgery. Considering that all solid organ transplants are critically dependent on the patency of vascular anastomosis, there is much concern about the consequences this pro-thrombotic condition may have on transplantation. Relatively little information is available in the literature assessing the real risk that antiphospholipid syndrome or the presence of antiphospholipid antibodies represent in solid organ transplantation. The aim of this article is to review the literature related to transplantation of solid organs in patients diagnosed with antiphospholipid syndrome or patients with positive antiphospholipid antibodies.

Keywords: Antiphospholipid syndrome; anticardiolipin antibodies; lupus anticoagulant; solid organ transplantation; thrombophilia.

Publication types

  • Review

MeSH terms

  • Antibodies, Anticardiolipin / immunology
  • Antibodies, Antiphospholipid / immunology*
  • Antiphospholipid Syndrome / diagnosis*
  • Antiphospholipid Syndrome / immunology
  • Antiphospholipid Syndrome / surgery
  • Female
  • Humans
  • Lupus Coagulation Inhibitor / immunology
  • Middle Aged
  • Organ Transplantation*
  • Risk Factors
  • Thrombophilia / diagnosis
  • Thrombophilia / etiology
  • Thrombophilia / therapy
  • Thrombosis / immunology
  • Thrombosis / physiopathology
  • Transplantation Immunology
  • Treatment Outcome

Substances

  • Antibodies, Anticardiolipin
  • Antibodies, Antiphospholipid
  • Lupus Coagulation Inhibitor