A Novel Tetradentate Ruthenium(II) Complex Containing Tris(2- Pyridylmethyl)amine (tpa) As An Inhibitor Of Beta-amyloid Fibrillation

Curr Alzheimer Res. 2015;12(5):434-8. doi: 10.2174/1567205012666150504150726.

Abstract

We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO(4) 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / metabolism*
  • Microscopy, Electron, Transmission
  • Molecular Structure
  • Neuroprotective Agents / chemical synthesis*
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / pharmacology*
  • Peptide Fragments / metabolism*
  • Protein Aggregates / drug effects*
  • Pyridines / chemistry
  • Pyridines / pharmacology*
  • Ruthenium / chemistry
  • Ruthenium / pharmacology*
  • Spectrum Analysis

Substances

  • Amyloid beta-Peptides
  • Neuroprotective Agents
  • Peptide Fragments
  • Protein Aggregates
  • Pyridines
  • amyloid beta-protein (1-40)
  • tris(2-pyridylmethyl)amine
  • Ruthenium