Abstract
We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO(4) 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amyloid beta-Peptides / metabolism*
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Microscopy, Electron, Transmission
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Molecular Structure
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Neuroprotective Agents / chemical synthesis*
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / pharmacology*
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Peptide Fragments / metabolism*
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Protein Aggregates / drug effects*
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Pyridines / chemistry
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Pyridines / pharmacology*
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Ruthenium / chemistry
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Ruthenium / pharmacology*
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Spectrum Analysis
Substances
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Amyloid beta-Peptides
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Neuroprotective Agents
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Peptide Fragments
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Protein Aggregates
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Pyridines
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amyloid beta-protein (1-40)
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tris(2-pyridylmethyl)amine
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Ruthenium