The iceLogo web server and SOAP service for determining protein consensus sequences

Davy Maddelein; Niklaas Colaert; Iain Buchanan; Niels Hulstaert; Kris Gevaert; Lennart Martens

doi:10.1093/nar/gkv385

The iceLogo web server and SOAP service for determining protein consensus sequences

Nucleic Acids Res. 2015 Jul 1;43(W1):W543-6. doi: 10.1093/nar/gkv385. Epub 2015 Apr 20.

Authors

Davy Maddelein¹, Niklaas Colaert¹, Iain Buchanan¹, Niels Hulstaert¹, Kris Gevaert¹, Lennart Martens²

Affiliations

¹ Department of Medical Protein Research, VIB, A. Baertsoenkaai 3, B-9000 Ghent, Belgium Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, A. Baertsoenkaai 3, B-9000 Ghent, Belgium.
² Department of Medical Protein Research, VIB, A. Baertsoenkaai 3, B-9000 Ghent, Belgium Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, A. Baertsoenkaai 3, B-9000 Ghent, Belgium lennart.martens@ugent.be.

Abstract

The iceLogo web server and SOAP service implement the previously published iceLogo algorithm. iceLogo builds on probability theory to visualize protein consensus sequences in a format resembling sequence logos. Peptide sequences are compared against a reference sequence set that can be tailored to the studied system and the used protocol. As such, not only over- but also underrepresented residues can be visualized in a statistically sound manner, which further allows the user to easily analyse and interpret conserved sequence patterns in proteins. The web application and SOAP service can be found free and open to all users without the need for a login on http://iomics.ugent.be/icelogoserver/main.html.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Amino Acid Sequence
Animals
Consensus Sequence*
Internet
Mice
Sequence Analysis, Protein / methods*
Software*