A luminescent cyclometalated gold(iii)-avidin conjugate with a long-lived emissive excited state that binds to proteins and DNA and possesses anti-proliferation capacity

Johnson Lui-Lui Tsai; Anna On-Yee Chan; Chi-Ming Che

doi:10.1039/c5cc00186b

A luminescent cyclometalated gold(iii)-avidin conjugate with a long-lived emissive excited state that binds to proteins and DNA and possesses anti-proliferation capacity

Chem Commun (Camb). 2015 May 18;51(40):8547-50. doi: 10.1039/c5cc00186b.

Authors

Johnson Lui-Lui Tsai¹, Anna On-Yee Chan, Chi-Ming Che

Affiliation

¹ State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Chemical Biology Center and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China. cmche@hku.hk.

PMID: 25896112
DOI: 10.1039/c5cc00186b

Abstract

Here we describe a luminescent cyclometalated Au(iii)-avidin conjugate that exhibits a 520 nm emission with a lifetime of 1.8 μs in PBS solution in open air. The conjugate stains proteins and DNA and can inhibit cancer cell proliferation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Apoptosis / drug effects
Avidin / chemistry*
Avidin / pharmacology
Biotin / chemistry*
Cell Line, Tumor
Cell Survival / drug effects
DNA / chemistry*
Gold / chemistry*
Gold / pharmacology
Humans
Serum Albumin, Bovine / chemistry*

Substances

Antineoplastic Agents
Avidin
Serum Albumin, Bovine
Biotin
Gold
DNA