Epigenetic signatures of obesity

N Engl J Med. 2015 Mar 5;372(10):973-4. doi: 10.1056/NEJMcibr1414707.

Abstract

A study in drosophila shows that the progeny of male flies briefly fed a diet with abnormally high or low sugar levels are more susceptible to obesity. The data suggest that epigenetic susceptibility factors are at play not only in flies but in humans and mice as well.

Publication types

  • Review

MeSH terms

  • Animals
  • Carbohydrates / administration & dosage
  • Chromatin / metabolism
  • Chromatin / ultrastructure
  • Chromosomal Proteins, Non-Histone / genetics
  • Chromosomal Proteins, Non-Histone / metabolism
  • Diet
  • Disease Models, Animal
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / metabolism
  • Epigenesis, Genetic*
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Methylation
  • Mice
  • Obesity / genetics*
  • Spermatozoa / metabolism
  • Transcription, Genetic
  • Triglycerides / analysis

Substances

  • Carbohydrates
  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • Drosophila Proteins
  • Triglycerides