Huntingtin facilitates selective autophagy

Nat Cell Biol. 2015 Mar;17(3):214-5. doi: 10.1038/ncb3125.

Abstract

Selective autophagy is essential for maintaining cellular homeostasis under different growth conditions. Huntingtin, mutated versions of which have been implicated in Huntington disease, is now shown to act as a scaffold protein that couples the induction of autophagy and the selective recruitment of cargo into autophagosomes.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autophagy / genetics*
  • Autophagy-Related Protein-1 Homolog
  • Drosophila Proteins
  • Drosophila melanogaster / genetics*
  • Humans
  • Huntingtin Protein
  • Intracellular Signaling Peptides and Proteins / genetics*
  • Microtubule-Associated Proteins / genetics*
  • Nerve Tissue Proteins / genetics*
  • Protein Serine-Threonine Kinases / genetics*
  • TOR Serine-Threonine Kinases / genetics*

Substances

  • Drosophila Proteins
  • HTT protein, human
  • Htt protein, Drosophila
  • Huntingtin Protein
  • Intracellular Signaling Peptides and Proteins
  • Microtubule-Associated Proteins
  • Nerve Tissue Proteins
  • MTOR protein, human
  • Autophagy-Related Protein-1 Homolog
  • Protein Serine-Threonine Kinases
  • TOR Serine-Threonine Kinases
  • ULK1 protein, human