Abstract
Selective autophagy is essential for maintaining cellular homeostasis under different growth conditions. Huntingtin, mutated versions of which have been implicated in Huntington disease, is now shown to act as a scaffold protein that couples the induction of autophagy and the selective recruitment of cargo into autophagosomes.
MeSH terms
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Animals
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Autophagy / genetics*
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Autophagy-Related Protein-1 Homolog
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Drosophila Proteins
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Drosophila melanogaster / genetics*
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Humans
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Huntingtin Protein
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Intracellular Signaling Peptides and Proteins / genetics*
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Microtubule-Associated Proteins / genetics*
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Nerve Tissue Proteins / genetics*
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Protein Serine-Threonine Kinases / genetics*
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TOR Serine-Threonine Kinases / genetics*
Substances
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Drosophila Proteins
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HTT protein, human
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Htt protein, Drosophila
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Huntingtin Protein
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Intracellular Signaling Peptides and Proteins
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Microtubule-Associated Proteins
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Nerve Tissue Proteins
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MTOR protein, human
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Autophagy-Related Protein-1 Homolog
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Protein Serine-Threonine Kinases
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TOR Serine-Threonine Kinases
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ULK1 protein, human