Novel encoding methods for DNA-templated chemical libraries

Gang Li; Wenlu Zheng; Ying Liu; Xiaoyu Li

doi:10.1016/j.cbpa.2015.01.004

Novel encoding methods for DNA-templated chemical libraries

Curr Opin Chem Biol. 2015 Jun:26:25-33. doi: 10.1016/j.cbpa.2015.01.004. Epub 2015 Jan 28.

Authors

Gang Li¹, Wenlu Zheng², Ying Liu¹, Xiaoyu Li³

Affiliations

¹ Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, Beijing National Laboratory of Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
² Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
³ Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, Beijing National Laboratory of Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China. Electronic address: xiaoyuli@pku.edu.cn.

PMID: 25635927
DOI: 10.1016/j.cbpa.2015.01.004

Abstract

Among various types of DNA-encoded chemical libraries, DNA-templated library takes advantage of the sequence-specificity of DNA hybridization, enabling not only highly effective DNA-templated chemical reactions, but also high fidelity in library encoding. This brief review summarizes recent advances that have been made on the encoding strategies for DNA-templated libraries, and it also highlights their respective advantages and limitations for the preparation of DNA-encoded libraries.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Binding Sites
Drug Discovery
Gene Expression
Gene Library*
Molecular Probes / chemistry
Nucleic Acid Hybridization
Peptide Library*
Peptide Nucleic Acids / chemical synthesis
Peptide Nucleic Acids / chemistry*
Small Molecule Libraries / chemical synthesis
Small Molecule Libraries / chemistry*

Substances

Molecular Probes
Peptide Library
Peptide Nucleic Acids
Small Molecule Libraries