Adenovirus-based vaccines against avian-origin H5N1 influenza viruses

Biao He; Bo-jian Zheng; Qian Wang; Lanying Du; Shibo Jiang; Lu Lu

doi:10.1016/j.micinf.2014.11.003

Adenovirus-based vaccines against avian-origin H5N1 influenza viruses

Microbes Infect. 2015 Feb;17(2):135-41. doi: 10.1016/j.micinf.2014.11.003. Epub 2014 Dec 3.

Authors

Biao He¹, Bo-jian Zheng², Qian Wang¹, Lanying Du³, Shibo Jiang⁴, Lu Lu⁵

Affiliations

¹ Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China.
² Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong 999077, China.
³ Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.
⁴ Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China; Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA. Electronic address: shibojiang@fudan.edu.cn.
⁵ Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China. Electronic address: lul@fudan.edu.cn.

Abstract

Since 1997, human infection with avian H5N1, having about 60% mortality, has posed a threat to public health. In this review, we describe the epidemiology of H5N1 transmission, advantages and disadvantages of different influenza vaccine types, and characteristics of adenovirus, finally summarizing advances in adenovirus-based H5N1 systemic and mucosal vaccines.

Keywords: Adenovirus; H5N1; Mucosal; Vaccine.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adenoviridae / immunology*
Animals
Birds
China / epidemiology
Communicable Disease Control
Humans
Influenza A Virus, H5N1 Subtype / immunology*
Influenza Vaccines / administration & dosage
Influenza Vaccines / immunology*
Influenza in Birds / virology*
Influenza, Human / epidemiology
Influenza, Human / prevention & control*
Influenza, Human / transmission
Influenza, Human / virology

Substances

Influenza Vaccines