First report of severe parainfluenza virus 4B and rhinovirus C coinfection in a liver transplant recipient treated with immunoglobulin

J Clin Virol. 2014 Dec;61(4):611-4. doi: 10.1016/j.jcv.2014.09.019. Epub 2014 Oct 8.

Abstract

We describe the first reported case of severe pneumonia due to coinfection by parainfluenza virus type 4B and rhinovirus C in a liver transplant recipient. The patient responded promptly to intravenous immunoglobulin and timely infection control measures prevented spreading of the infections. This report highlights respiratory viral coinfections as a possible cause of severe morbidity in transplant recipients and the importance of efficient molecular diagnostic technologies with major impact on clinical practice in a transplant center. It also describes a potential therapeutic strategy for such patients.

Keywords: Coinfection; Immunoglobulin; Parainfluenza; Rhinovirus; Transplantation.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Coinfection / diagnosis*
  • Coinfection / pathology
  • Coinfection / virology
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use*
  • Liver Transplantation
  • Male
  • Parainfluenza Virus 4, Human / isolation & purification*
  • Picornaviridae Infections / diagnosis*
  • Picornaviridae Infections / pathology
  • Picornaviridae Infections / virology
  • Pneumonia, Viral / diagnosis
  • Pneumonia, Viral / pathology
  • Pneumonia, Viral / virology
  • Rhinovirus / isolation & purification*
  • Rubulavirus Infections / diagnosis*
  • Rubulavirus Infections / pathology
  • Rubulavirus Infections / virology
  • Transplant Recipients*
  • Treatment Outcome

Substances

  • Immunoglobulins, Intravenous