Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Escherichia coli isolates

J Microbiol Immunol Infect. 2016 Feb;49(1):123-6. doi: 10.1016/j.jmii.2014.08.012. Epub 2014 Nov 1.

Abstract

Aminoglycoside resistance determinants among 188 aminoglycoside-resistant blood culture Escherichia coli isolates from a tertiary hospital in Hong Kong, from 2004 to 2010 were investigated. Overall, 91% had aac(3)-II, 12.2% had aac(6')-Ib/Ib-cr, and 5.4% had the methylase genes (rmtB, armA). Aminoglycoside-resistant isolates with aac(')-Ib/Ib-cr, rmtB, and armA often had coresistance to multiple other antibiotics.

Keywords: aminoglycoside resistance; molecular epidemiology; multidrug resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetyltransferases / genetics*
  • Aminoglycosides / pharmacology*
  • Anti-Bacterial Agents / pharmacology*
  • Drug Resistance, Bacterial*
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / microbiology
  • Hong Kong
  • Humans
  • Prevalence
  • Tertiary Care Centers
  • tRNA Methyltransferases / genetics*

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • tRNA Methyltransferases
  • Acetyltransferases