The neuroprotective activity of apolipoprotein E (apoE) peptide mimetic Cog1410, containing amino acid sequence of the receptor-binding domain apoE, has been investigated in transgenic lines of Drosophila melanogaster expressing human APP and beta-secretase. Expression of two transgenes caused neuropathological processes attributed to Alzheimer's disease: neurodegeneration, cognitive abnormality and amyloid deposits formation in brain. It was shown that Cog 1410 reduces neurodegeneration in brain of transgenic flies and improves cognitive functions (odor recognition). These data suggest that Cog1410 is a potential neuroprotector that can be used in AD treatment.
Na transgennykh liniiakh Drosophila melanogaster s ékspressieĭ genov cheloveka ARR i beta-sekretazy, provedeno izuchenie neĭroprotektornykh svoĭstv peptidnogo mimetika apolipoproteina E, Sog1410, vkliuchaiushchego aminokislotnuiu posledovatel'nost' retseptor-sviazyvaiushchego domena apoE. Ékspressiia dvoĭnykh transgenov vyzyvala neĭropatologicheskie protsessy, kharakternye dlia bolezni Al'tsgeĭmera (BA): neĭrodegeneratsiiu, narushenie kognitivnye funktsiĭ i nakoplenie v mozge agregatov amiloid-beta proteina. Pokazano, chto Cog1410 umen'shaet neĭrodegeneratsiiu v mozge transgennykh mukh i vosstanavlivaet kognitivnye funktsii (sposobnost' k raspoznavaniiu zapakhov). Poluchennye rezul'taty pozvoliaiut predpolozhit', chto Cog1410 iavliaetsia perspektivnym neĭroprotektorom dlia razrabotki terapii BA.
Keywords: Cog1410; Drosophila melanogaster; apoE.