Triple-responsive expansile nanogel for tumor and mitochondria targeted photosensitizer delivery

Biomaterials. 2014 Nov;35(35):9546-53. doi: 10.1016/j.biomaterials.2014.08.004. Epub 2014 Aug 22.

Abstract

A pH, thermal, and redox potential triple-responsive expansile nanogel system (TRN), which swells at acidic pH, temperature higher than its transition temperature, and reducing environment, has been developed. TRN quickly expands from 108 nm to over 1200 nm (in diameter), achieving more than 1000-fold size enlargement (in volume), within 2 h in a reducing environment at body temperature. Sigma-2 receptor targeting-ligand functionalized TRN can effectively target head and neck tumor, and help Pc 4 targeting mitochondria inside cancer cells to achieve enhanced photodynamic therapy efficacy.

Keywords: Expandable; Nanoparticle; Photodynamic therapy; Stimuli-responsive; Tumor targeted.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Drug Carriers / chemistry
  • Drug Delivery Systems / methods
  • Gels / chemistry
  • Gels / pharmacokinetics*
  • Head and Neck Neoplasms / drug therapy
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Mice
  • Microscopy, Confocal
  • Mitochondria / drug effects*
  • Mitochondria / metabolism
  • Nanoparticles / chemistry*
  • Photochemotherapy / methods
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacokinetics*
  • Receptors, sigma / genetics
  • Receptors, sigma / metabolism
  • Temperature
  • Tissue Distribution
  • Xenograft Model Antitumor Assays

Substances

  • Drug Carriers
  • Gels
  • Photosensitizing Agents
  • Receptors, sigma
  • sigma-2 receptor