Pharmacologic management of bipolar disorder in a Medicare Advantage population

Psychosomatics. 2014 Nov-Dec;55(6):572-7. doi: 10.1016/j.psym.2014.02.005. Epub 2014 Apr 19.

Abstract

Objective: The purpose of this study was to examine patterns of pharmacotherapy for beneficiaries in a high-risk Medicare Advantage program who were diagnosed with bipolar disorder.

Methods: This was a cross-sectional study of 2338 Medicare Advantage beneficiaries diagnosed with bipolar disorder. Pharmacotherapy treatment was assessed via receipt of (1) a mood stabilizer or antipsychotic or both (i.e., guideline concordant bipolar care) and (2) unopposed antidepressant (i.e., without prescription of a mood stabilizer or an antipsychotic). Logistic regression was used to examine correlates of bipolar disorder care.

Results: Among those younger than 65 years of age (n = 1395), 54% received guideline concordant therapy and 29% received unopposed antidepressant therapy. Among those 65 years and older (n = 943), 40% received guideline concordant therapy and 33% received unopposed antidepressant therapy.

Conclusion: Overall, about half of beneficiaries in this Medicare Advantage plan received guideline concordant pharmacotherapy for bipolar disorder, while approximately one-third received an unopposed antidepressant prescription. Antipsychotic medications accounted for most of the monotherapy observed. This study identifies opportunities for further improvements in the pharmacotherapy of bipolar disorder in high-risk Medicare patients.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Age Factors
  • Aged
  • Antidepressive Agents / administration & dosage
  • Antidepressive Agents / therapeutic use
  • Antipsychotic Agents / administration & dosage
  • Antipsychotic Agents / therapeutic use
  • Bipolar Disorder / drug therapy*
  • Cross-Sectional Studies
  • Drug Therapy, Combination
  • Female
  • Guideline Adherence / statistics & numerical data
  • Humans
  • Male
  • Medicare Part C* / statistics & numerical data
  • Middle Aged
  • United States

Substances

  • Antidepressive Agents
  • Antipsychotic Agents